Pretty specific huh? Well the thing is I have the exact same card reader, OS, version on one Lenovo laptop. The SD card works on the Lenovo, but not on the Dell Inspiron 3421.
The error it made on the Dell was the following in /var/log/syslog
Feb 14 08:30:46 raspberry kernel: [ 216.319736] mmc0: error -22 whilst initialising SD card
Feb 14 08:30:48 raspberry kernel: [ 219.151052] mmc0: tuning execution failed: -22
Lots of googling down dead ends ensued. Here's a little more info about the device in question.