I decided to encrypt the /home directory on a notebook, post install, as I was going to take it out of the house. There's nothing too important on it, but I probably should look after my ssh keys at least! The laptop is a low end Dell, running Mint (based on Ubuntu). It has a slightly odd configuration in that I have the /home partition mounted separately.
OK, so the first thing I did was to copy the big files onto a separate, non-encrypted partition. I did this for two reasons. Firstly the encryption process creates a copy of your home directory which you can roll back to. This means in your /home partition you need enough room for two copies of your home dir. I didn't. Secondly, the encryption process obviously encrypts each file as it goes. I thought by moving out the large files (Music and Videos directories basically), that this would speed up the encryption process.